BAD anticorps (pThr80)

N° du produit ABIN1881100

Cet anticorps Lapin Polyclonal détecte spécifiquement BAD dans DB. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour BAD anticorps (pThr80) (ABIN1881100)

Antigène: BAD (BCL2-Associated Agonist of Cell Death (BAD))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAD est non-conjugé

Application: Dot Blot (DB)

Clone: RB39409

Détail du produit anti-BAD anticorps

Épitope: pThr80

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This BAD Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T80 of human BAD.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-BAD (ABIN1881100)

Galmiche, Ezzoukhry, François, Louandre, Sabbagh, Nguyen-Khac, Descamps, Trouillet, Godin, Regimbeau, Joly, Barbare, Duverlie, Mazière, Chatelain: "BAD, a proapoptotic member of the BCL2 family, is a potential therapeutic target in hepatocellular carcinoma." dans: Molecular cancer research : MCR, Vol. 8, Issue 8, pp. 1116-25, (2010) (PubMed).

Yu, Sun, Shen, Gao, Fan, Sun: "Expression of the apoptosis-related genes BCL-2 and BAD in human breast carcinoma and their associated relationship with chemosensitivity." dans: Journal of experimental & clinical cancer research : CR, Vol. 29, pp. 107, (2010) (PubMed).

Détails sur BAD

Antigène: BAD (BCL2-Associated Agonist of Cell Death (BAD))

Autre désignation: BAD

Sujet: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq].

Poids moléculaire: 18392

NCBI Accession: NP_004313, NP_116784

UniProt: Q92934

Pathways: Signalisation MAPK, Signalisation PI3K-Akt, Signalisation RTK, Apoptose, Fc-epsilon Receptor Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events